Influence of interferon on virus‐particle synthesis in oncornavirus‐carrier lines. II. Evidence for A direct effect on particle release

Interferon treatment of murine C‐type oncornavirus carrier lines results in a drastic inhibition of extracellular virus formation. When such cells are subcultured in the presence of interferon, synthesis of extracellular C‐type virus remains depressed until the interferon treatement is discontinued. Cell‐associated virus as seen in the electron microscope or as detected by uridine incorporation is not proportionally inhibited. Several possibilities to explain this discrepancy are tested. The most likely hypothesis is that interferon treatment primarily inhibits virus release.