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December 22, 1978Science

Human Leukocyte Interferon Purified to Homogeneity

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Population

Human leukocytes incubated with Newcastle disease virus

Design

Preclinical

Authors

MRMenachem RubinsteinWeizmann Institute of ScienceSRSara RubinsteinMedical Council of CanadaPFPhilip C. FamillettiRoche (Switzerland)

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Overview

Enables precise interferon characterization; extends purification methods but leaves open human therapeutic translation.

Structured PICO

P
Population
Human leukocytes incubated with Newcastle disease virus
I
Intervention
Purification of human interferon
O
Outcome
Homogeneity of purified human interferon (single peak of activity coinciding with a single protein band on SDS-PAGE)surrogate

Demonstrates the successful purification of a species of human leukocyte interferon to homogeneity.

Cite This Study

Rubinstein et al. (1978) studied this question.

synapsesocial.com/papers/6a866a96cdf6ddc25c8332e2https://doi.org/10.1126/science.725605
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human leukocyte interferon: production, purification to homogeneity, and initial characterization.1979 · 234 citations
  2. 2Affinity Chromatography of Human Leukocyte and Diploid Cell Interferons on Sepharose-Bound Antibodies1975 · 85 citations
  3. 3Partial Purification of Human Interferon by Affinity Chromatography1974 · 74 citations
  4. 4Virus Replication and High-Titered Interferon Production in Human Leukocyte Cultures Inoculated with Newcastle Disease Virus1966 · 90 citations
  5. 5Purification of interferon from mouse Ehrlich ascites tumor cells.1978 · 84 citations