Why the study?
TAVR performance strongly depends on calcification patterns, which may cause stented valve malapposition and complications including paravalvular leakage.
How do different calcification patterns impact transcatheter aortic valve performance and paravalvular leakage in computational models?
Population
One anatomical-resembling aortic root model with six calcific deposit configurations
Comparison
Different calcification patterns (deposits along cusps coaptation vs along the attachment line)
Design
Fluid-structure interaction simulation study
Authors
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Calcification patterns may alter simulated TAVR kinematics and PVL risk; leaves open whether patient-specific modeling refines procedural planning.
How do different calcification patterns impact transcatheter aortic valve performance and paravalvular leakage in computational models?
Computational modeling demonstrates that the specific anatomical location of aortic root calcification significantly influences the severity of paravalvular leakage following TAVR.
Luraghi et al. (2020) studied this question.
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