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June 1, 2025Biomechanics and Modeling in MechanobiologyOpen Access

A reduced 3D-0D fluid–structure interaction model of the aortic valve that includes leaflet curvature

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Why the study?

Existing phenomenological-based models of the aortic valve typically require numerous parameters, prompting the need for an efficient model that allows easier calibration while simulating valve dynamics on blood flow.

Population

Physiological and stenotic aortic valve configurations

Comparison

Different treatments for leaflet velocity

Design

Computational fluid-structure interaction modeling study

Authors

IFIvan FumagalliPolitecnico di MilanoLDLuca Dede’ElectrophysiologyAQAlfio QuarteroniGeneral Cardiology

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Implication

Does not yet alter aortic stenosis management; extends in silico tools for hypothesis generation in valve hemodynamics.

Structured PICO

P
Population
Computational model of the aortic valve (physiological and stenotic configurations)
I
Intervention
Reduced 3D-0D fluid-structure interaction model including leaflet curvature coupled to 3D Navier-Stokes equations
O
Outcome
Representation of leaflet motion, blood flow in the ascending aorta, and pressure jump across the leaflets

This innovative lumped-parameter model efficiently simulates aortic valve dynamics and blood flow, offering easier calibration than phenomenological models.

Cite This Study

Fumagalli et al. (2025) studied this question.

synapsesocial.com/papers/6a866eea62a2c4ca750f7aa2https://doi.org/10.1007/s10237-025-01960-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of a transient, simultaneous, arbitrary Lagrange–Euler based multi-physics method for simulating the mitral heart valve2012 · 47 citations
  2. 2Thinner biological tissues induce leaflet flutter in aortic heart valve replacements2020 · 100 citations
  3. 3Effect of leaflet-to-chordae contact interaction on computational mitral valve evaluation2014 · 18 citations
  4. 4Calcific Aortic Stenosis — Time to Look More Closely at the Valve2008 · 193 citations
  5. 5An unfitted Nitsche method for incompressible fluid–structure interaction using overlapping meshes2014 · 109 citations