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October 1, 1993Annals of Neurology

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

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Authors

PMPatrizia MecocciUniversity of PerugiaUMUsha MacGarveyMassachusetts General HospitalAKA. KaufmanEmory University

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Mecocci et al. (1993) studied this question.

synapsesocial.com/papers/6a8672fc4303a53bb82fd336https://doi.org/10.1002/ana.410340416
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multiple mitochondrial DNA deletions in an elderly human individual1992 · 217 citations
  2. 2Local cerebral glucose utilization in the normal conscious macaque monkey1978 · 245 citations
  3. 38-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.1992 · 1,863 citations
  4. 4Normal oxidative damage to mitochondrial and nuclear DNA is extensive.1988 · 1,732 citations
  5. 5A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.1992 · 644 citations