Why the study?
Does G-CSF alter the mobilization of CD34+ and mesenchymal stem cells in patients with STEMI treated with primary PCI?
Population
78 patients with ST-elevation myocardial infarction treated with primary percutaneous intervention <12 hours…
Comparison
Granulocyte-colony stimulating factor 10… vs Double-blind placebo
Design
RCT, randomized, double-blind
Follow-up
7 days
Authors
Loading...
G-CSF differentially mobilizes progenitor subsets after STEMI; extends mechanistic understanding of its neutral effects in prior outcome trials.
Does G-CSF alter the mobilization of CD34+ and mesenchymal stem cells in patients with STEMI treated with primary PCI?
G-CSF administration after STEMI increases CD34+ cell mobilization but decreases the fraction of circulating mesenchymal stem cells, which inversely correlates with systolic recovery.
Ripa et al. (2007) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: