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October 1, 1990Journal of Biological ChemistryOpen Access

Identification of a chromosome 6-encoded dystrophin-related protein.

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Population

Recombinant bacterial protein expression system and tissue samples from patients with Duchenne and Becker…

Design

Preclinical

Authors

TKT.S. KhuranaMayo Clinic in ArizonaEHEric P. HoffmanAGADA BiosciencesLKLouis M. KunkelPediatric Cardiology

Discussion

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Implication

Should not alter dystrophy management; leaves open the functional role of this novel protein across tissues.

Structured PICO

P
Population
Recombinant bacterial protein expression system and tissue samples from patients with Duchenne and Becker muscular dystrophies
I
Intervention
Polymerase chain reaction cloning and expression of chromosome 6-encoded cDNA, followed by antibody detection
O
Outcome
Detection and characterization of a dystrophin-related proteinsurrogate

The study identifies a novel chromosome 6-encoded dystrophin-related protein that is expressed in multiple tissues and remains detectable in patients with Duchenne and Becker muscular dystrophies.

Cite This Study

Khurana et al. (1990) studied this question.

synapsesocial.com/papers/6a8674c0da4bf993812ee1fahttps://doi.org/10.1016/s0021-9258(17)44816-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunocytochemical study of dystrophin at the myotendinous junction1990 · 91 citations
  2. 2Sequence similarity of the amino-terminal domain of Drosophila beta spectrin to alpha actinin and dystrophin.1989 · 149 citations
  3. 3Conservation of the Duchenne Muscular Dystrophy Gene in Mice and Humans1987 · 256 citations
  4. 4Detection of a specific isoform of alpha-actinin with antisera directed against dystrophin.1989 · 46 citations
  5. 5Asymmetric distribution of dystrophin in developing and adult Torpedo marmorata electrocyte: evidence for its association with the acetylcholine receptor-rich membrane.1990 · 58 citations