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The effect of treatment with interferon (IF) preparations on tumor development in Rill and C57BL mice was evaluated. A significant retardation in appearance of tumors occurred when IF was given to young Rill mice (6 weeks old), but a diminution of the effect was observed if IF was given when the mice were 22 weeks old. When the milk from Rill mice treated early in life was examined for mammary tumor virus antigen by immunodiffusion, no reduction in incidence was observed though a significant delay in tumorigenesis resulted. When IF treatment was delayed until late in the life of C57BL mice, no protection was observed.
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Came et al. (1972) studied this question.
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