This is the first report of late thrombosis of a sirolimus-eluting stent, highlighting the potential risk of discontinuing dual antiplatelet therapy early.
May warrant caution with early clopidogrel discontinuation after sirolimus-eluting stents; leaves open optimal dual antiplatelet therapy duration.
Late stent thrombosis in the era of routine high-pressure stent deployment and combined antiplatelet therapy with thienopyridines and aspirin has become a rare but feared complication. We describe a patient with acute myocardial infarction due to late stent thrombosis 6 weeks after deployment of a sirolimus-eluting stent and 2 weeks after the discontinuation of clopidogrel. This is the first report of late thrombosis of a sirolimus-eluting stent.
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Kerner et al. (2003) studied this question.
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