Why the study?
Does eprosartan improve blood pressure reduction compared to enalapril in patients with severe hypertension?
Population
118 patients with severe hypertension (sitting diastolic blood pressure [sitDBP] >= 115 mmHg and <= 125 mmHg).
Comparison
Oral eprosartan starting at 400 mg total daily… vs Oral enalapril starting at 10 mg total daily…
Design
RCT, randomized, double-blind
Follow-up
10 weeks
Authors
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Eprosartan may be preferred over enalapril for SBP control in severe hypertension; extends head-to-head ARB versus ACEI comparisons.
Does eprosartan improve blood pressure reduction compared to enalapril in patients with severe hypertension?
In patients with severe hypertension, eprosartan is as effective as enalapril in reducing diastolic blood pressure but more effective in reducing systolic blood pressure.
Roberto Sega (1999) studied this question.
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