Why the study?
Do body composition, fasting leptin, and sex steroid administration determine GH sensitivity in peripubertal short children?
Do body composition, fasting leptin, and sex steroid administration determine GH sensitivity in peripubertal short children?
GH sensitivity is determined by fat mass, serum fasting leptin, C-peptide, and FFA, and is divergently affected by oral ethinyl estradiol and intramuscular testosterone.
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Supports adiposity and leptin as modulators of GH sensitivity in short children; hypothesis-generating and requires prospective validation before clinical consideration.
Coutant et al. (2001) studied this question.
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