What question did this study set out to answer?

To determine whether the surge of progesterone secreted during proestrus terminates the estrogen-induced neural signal driving daily preovulatory luteinizing hormone surges.

July 1, 1976Endocrinology

Extinction of the Estrogen-Induced Daily Signal for LH Release in the Rat: A Role for the Proestrous Surge of Progesterone

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Authors

MFM. C. FREEMANFlorida State University KDK. C. DUPKEFlorida State University CCC. M. CROTEAUFlorida State University

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Implication

Controlled animal study demonstrates that proestrous progesterone blocks recurring daily luteinizing hormone surges in rats, indicating a hormonal shutoff mechanism for ovulatory signaling.

Key Points

To determine whether the surge of progesterone secreted during proestrus terminates the estrogen-induced neural signal driving daily preovulatory luteinizing hormone surges.
Treated ovariectomized rats with 50 µg estradiol benzoate to stimulate daily luteinizing hormone surges, administering 5 mg progesterone at 1600 h on day 1 in the intervention group.
Administered sodium pentobarbital at 1345 h on proestrus to cycling rats to delay endogenous hormone surges, then simulated the progesterone surge using 5 mg progesterone at 1400 h.
Estradiol benzoate triggered consecutive daily luteinizing hormone surges for 3 days in ovariectomized rats, but 5 mg progesterone at 1600 h on day 1 eliminated surges on days 2 and 3.
In pentobarbital-blocked cycling rats, simulating the proestrous progesterone surge at 1400 h prevented preovulatory luteinizing hormone release during proestrus, estrus, and diestrus-1.

Cite This Study

FREEMAN et al. (1976) studied this question.

synapsesocial.com/papers/6a86841c519fe6d758cc6bfa https://doi.org/10.1210/endo-99-1-223

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Implication

Controlled animal study demonstrates that proestrous progesterone blocks recurring daily luteinizing hormone surges in rats, indicating a hormonal shutoff mechanism for ovulatory signaling.

Extinction of the Estrogen-Induced Daily Signal for LH Release in the Rat: A Role for the Proestrous Surge of Progesterone

Discussion

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Implication

Key Points

Cite This Study

Extinction of the Estrogen-Induced Daily Signal for LH Release in the Rat: A Role for the Proestrous Surge of Progesterone

Discussion

Member takes

Implication

Key Points

Cite This Study

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