Why the study?
Does protein C replacement therapy reduce morbidity and mortality in patients with severe meningococcal septicemia, purpura fulminans, and multiorgan failure?
Does protein C replacement therapy reduce morbidity and mortality in patients with severe meningococcal septicemia, purpura fulminans, and multiorgan failure?
Protein C replacement therapy in severe meningococcal septicemia is associated with a reduction in predicted morbidity and mortality.
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Protein C replacement was associated with lower-than-predicted mortality and amputations in this cohort; hypothesis-generating and requires randomized confirmation before practice change.
White et al. (2000) studied this question.
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