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March 1, 1989Proceedings of the National Academy of SciencesOpen Access

Coordinate viral induction of tumor necrosis factor alpha and interferon beta in human B cells and monocytes.

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Population

Human B cells and monocytes (cell lines U937, Namalwa, JY)

Design

Preclinical

Authors

AGAnne E. GoldfeldBrigham and Women's HospitalTMT ManiatisNew York Genome Center

Discussion

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Implication

May support overlapping antiviral cytokine pathways; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
Human B cells and monocytes (cell lines U937, Namalwa, JY)
I
Intervention
Viral infection, phorbol 12-myristate 13-acetate, kinase inhibitor 2-aminopurine, and cycloheximide
O
Outcome
Expression of TNF-alpha and interferon beta mRNAsurrogate

Viral induction of TNF-alpha and interferon beta gene expression in human B cells and monocytes may involve overlapping pathways with both common and distinct regulatory factors.

Cite This Study

Goldfeld et al. (1989) studied this question.

synapsesocial.com/papers/6a868b8abc8a8c5c5ad09cc8https://doi.org/10.1073/pnas.86.5.1490
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