Why the study?
Does ischaemic preconditioning improve post-ischaemic mechanical performance in isolated hearts from transgenic hypertensive rats compared to normotensive controls?
Population
Isolated hearts from male transgenic (27) hypertensive rats and normotensive controls
Comparison
Ischaemic preconditioning prior to 30 min global… vs Continuous perfusion prior to 30 min global…
Design
Preclinical
Follow-up
60 min of reperfusion
Authors
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Enhanced preconditioning in hypertensive rat hearts warrants clinical caution; leaves open translation and AT1 mechanisms to human ischaemic preconditioning.
Does ischaemic preconditioning improve post-ischaemic mechanical performance in isolated hearts from transgenic hypertensive rats compared to normotensive controls?
Ischaemic preconditioning provides substantially enhanced cardioprotection in isolated hearts from transgenic hypertensive rats compared to normotensive controls, with diastolic protection partially mediated by AT1-receptors.
Michael D. Randall (1997) studied this question.
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