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January 1, 1991Japanese Circulation Journal-english EditionOpen Access

Effects of amiloride and an analogue on ventricular arrhythmias, contracture and cellular injury during reperfusion in isolated and perfused guinea pig heart.

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Why the study?

Does amiloride or EIPA prevent ventricular arrhythmias and myocardial injury during reperfusion in isolated and perfused guinea pig hearts?

Population

Isolated and perfused guinea pig hearts subjected to 15 or 30 min of global ischemia

Comparison

1 mM amiloride or 3 microM 5- amiloride… vs Untreated control hearts (implied)

Design

Preclinical

Authors

HOHajime OtaniYKY. KatoTKTokumitsu Ko

Discussion

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Overview

Amiloride and EIPA protect against reperfusion-induced ventricular arrhythmias and myocardial cellular injury in isolated guinea pig hearts, likely via inhibition of Na+/H+ and Na+/Ca2+ exchange.

Structured PICO

Does amiloride or EIPA prevent ventricular arrhythmias and myocardial injury during reperfusion in isolated and perfused guinea pig hearts?

P
Population
Isolated and perfused guinea pig hearts subjected to 15 or 30 min of global ischemia
I
Intervention
1 mM amiloride or 3 microM 5-(N-ethyl-N-isopropyl) amiloride (EIPA) administered for 15 min before ischemia and during reperfusion, or only during reperfusion
C
Comparator
Untreated control hearts (implied)
O
Outcome
Incidence of ventricular arrhythmias (ventricular tachycardia and ventricular fibrillation), isovolumic left ventricular function (LVEDP), and creatine kinase (CK) release during reperfusionsurrogate

Amiloride and EIPA protect against reperfusion-induced ventricular arrhythmias and myocardial cellular injury in isolated guinea pig hearts, likely via inhibition of Na+/H+ and Na+/Ca2+ exchange.

Cite This Study

Otani et al. (1991) studied this question.

synapsesocial.com/papers/6a868cb607201076d354497bhttps://doi.org/10.1253/jcj.55.845
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