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December 1, 1994AJP Heart and Circulatory Physiology

Na+/H+ exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor

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Why the study?

Do Na+/H+ exchange inhibitors reduce reperfusion-induced ventricular fibrillation in isolated rat hearts subjected to ischemia and reperfusion?

Population

Isolated rat hearts subjected to independent dual coronary perfusion with 10 min of left coronary bed…

Comparison

Intracoronary infusion of Na+/H+ exchange… vs Control group subjected to the same…

Design

Preclinical

Follow-up

5 minutes of reperfusion

Authors

MYMasahiro YasutakeCIChikao IbukiDHDavid J. Hearse

Discussion

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Overview

Inhibition of Na+/H+ exchange with EIPA or HOE-694 during early reperfusion significantly reduces reperfusion-induced ventricular fibrillation in an isolated rat heart model.

Structured PICO

Do Na+/H+ exchange inhibitors reduce reperfusion-induced ventricular fibrillation in isolated rat hearts subjected to ischemia and reperfusion?

P
Population
Isolated rat hearts (n = 12/group) subjected to independent dual coronary perfusion with 10 min of left coronary bed ischemia followed by 5 min of reperfusion.
I
Intervention
Intracoronary infusion of Na+/H+ exchange inhibitors 5-(N-ethyl-N-isopropyl)amiloride (EIPA) or 3-methylsulfonyl-4-piperidinobenzoyl guanidine (HOE-694) at 0.01, 0.1, 1, and 10 microM into the left coronary bed either during the 5-min period preceding ischemia plus during reperfusion or during reperfusion alone.
C
Comparator
Control group subjected to the same ischemia/reperfusion protocol without the active inhibitors.
O
Outcome
Incidence of reperfusion-induced ventricular fibrillation (VF) and percentage of hearts in sinus rhythm at the end of 5 min of reperfusion.surrogate

Inhibition of Na+/H+ exchange with EIPA or HOE-694 during early reperfusion significantly reduces reperfusion-induced ventricular fibrillation in an isolated rat heart model.

Cite This Study

Yasutake et al. (1994) studied this question.

synapsesocial.com/papers/6a98d8317a0bd180b0e10d04https://doi.org/10.1152/ajpheart.1994.267.6.h2430
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of amiloride and an analogue on ventricular arrhythmias, contracture and cellular injury during reperfusion in isolated and perfused guinea pig heart.1991 · 6 citations
  2. 2New Na(+)-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2+ overload in isolated perfused rabbit heart.1994 · 171 citations
  3. 3Impact of extracellular buffer composition on cardioprotective efficacy of Na+/H+ exchanger inhibitors1996 · 47 citations
  4. 4Role for the Na+/H+ Exchanger in Reperfusion Stunning in Isolated Perfused Rat Heart1993 · 49 citations
  5. 5Effects of a New Na+/H+ Antiporter Inhibitor on Postischemic Reperfusion in Pig Heart1994 · 75 citations