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June 1, 1994CirculationOpen Access

New Na(+)-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2+ overload in isolated perfused rabbit heart.

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Why the study?

Does the Na(+)-H+ exchange inhibitor HOE 694 improve postischemic function and reduce injury in isolated perfused rabbit hearts?

Population

Isolated perfused rabbit hearts subjected to 45 minutes of global normothermic ischemia followed by…

Comparison

HOE 694 administered either before ischemia or… vs Vehicle only (control group)

Design

Preclinical

Follow-up

45 minutes of ischemia followed by 1 hour of reperfusion

Authors

MHMarc HendrikxKMKanigula MubagwaKOK. Overloop

Discussion

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Overview

HOE 694 attenuates reperfusion diastolic dysfunction in rabbit hearts; leaves open translation of Na+/H+ exchange inhibition to clinical reperfusion injury.

Structured PICO

Does the Na(+)-H+ exchange inhibitor HOE 694 improve postischemic function and reduce injury in isolated perfused rabbit hearts?

P
Population
Isolated perfused rabbit hearts subjected to 45 minutes of global normothermic (37 degrees C) ischemia followed by reperfusion
I
Intervention
HOE 694 (1 mumol/L) administered either before ischemia (pretreatment) or only during reperfusion
C
Comparator
Vehicle only (control group)
O
Outcome
Postischemic function (end-diastolic pressure rise, left ventricular developed pressure, and dP/dt) at 1 hour of reperfusionsurrogate

In a preclinical rabbit heart model, the Na(+)-H+ exchange inhibitor HOE 694 improved postischemic functional recovery and cellular energetics, particularly when administered prior to ischemia.

Cite This Study

Hendrikx et al. (1994) studied this question.

synapsesocial.com/papers/6a7d19b8a88f8d6a789fff55https://doi.org/10.1161/01.cir.89.6.2787
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