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January 1, 1994Journal of Cardiovascular Pharmacology75 citations

Effects of a New Na+/H+ Antiporter Inhibitor on Postischemic Reperfusion in Pig Heart

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Why the study?

Does HOE 694 improve regional wall function and prevent ventricular fibrillation in a porcine model of ischemia/reperfusion?

Population

Porcine model of ischemia/reperfusion induced by coronary occlusion (n=19)

Comparison

HOE 694 7 mg/kg bolus 20 min before ischemia… vs Vehicle

Design

Preclinical

Follow-up

4 hours

Key result

HOE 694 significantly improved regional wall function (% segment shortening 74.1 vs 50.9, p<0.005) and completely prevented ventricular fibrillation in a porcine model of ischemia/reperfusion.

Authors

SSStefan SackMMMasahiro MohriESErnst R. Schwarz

Discussion

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Overview

Hypothesis-generating for Na+/H+ inhibition in ischemia/reperfusion; should not change clinical practice without human trials.

Structured PICO

Does HOE 694 improve regional wall function and prevent ventricular fibrillation in a porcine model of ischemia/reperfusion?

P
Population
19 pigs in a model of ischemia/reperfusion followed for a 4-hour reperfusion period.
I
Intervention
HOE 694 (3-methylsulfonyl-4-piperidinobenzoyl guanidine hydrochloride) 7 mg/kg bolus 20 min before ischemia followed by 0.07 mg/kg continuous infusion
C
Comparator
Vehicle
O
Outcome
Regional wall function (percentage of segment shortening) after 4-h reperfusionsurrogate

Inhibition of the Na+/H+ antiporter with HOE 694 diminishes myocardial ischemic cell injury and prevents ventricular fibrillation in a porcine model.

Main Result

Absolute Event Rate: 74.1% vs 50.9%

p-value: p=< 0.005

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Cite This Study

Sack et al. (1994) studied Ischemia/reperfusion (n=19). HOE 694 vs. Vehicle was evaluated on Regional wall function (percentage of segment shortening) (p=< 0.005). HOE 694 significantly improved regional wall function (% segment shortening 74.1 vs 50.9, p<0.005) and completely prevented ventricular fibrillation in a porcine model of ischemia/reperfusion.

synapsesocial.com/papers/6a221b9ae8ef4064f24ebec5https://doi.org/10.1097/00005344-199401000-00009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1New Na(+)-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2+ overload in isolated perfused rabbit heart.1994 · 171 citations
  2. 2Preischaemic as well as postischaemic application of a Na+/H+ exchange inhibitor reduces infarct size in pigs1995 · 40 citations
  3. 3Time Delay of Cell Death by Na+/H+-Exchange Inhibition in Regionally Ischemic, Reperfused Porcine Hearts1997 · 65 citations
  4. 4Myocardial Protection by Na<sup>+</sup>-H<sup>+</sup>Exchange Inhibition in Ischemic, Reperfused Porcine Hearts1995 · 126 citations
  5. 5Na+/H+ exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor1994 · 85 citations