What is the clinical evidence from this study?

Study design: Other. Population: Cardiac ischaemia and reperfusion. Intervention: Hoe 694 vs. Untreated/control hearts. Primary outcome: Reperfusion arrhythmias and cellular damage indicators (LDH and CK).

What question did this study set out to answer?

This research aims to evaluate the cardioprotective role of Hoe 694, a Na+/H+ exchange inhibitor, in cardiac ischaemia.

June 1, 1993British Journal of PharmacologyOpen Access

Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemia

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Key result

In rat models of cardiac ischaemia and reperfusion, the Na+/H+ exchange inhibitor Hoe 694 abolished reperfusion arrhythmias and reduced cellular damage indicators LDH and CK by 60% and 54%.

Why the study?

Does the Na+/H+ exchange inhibitor Hoe 694 reduce reperfusion arrhythmias and cellular damage in rat models of cardiac ischaemia?

Population

Rabbit erythrocytes, rat platelets, bovine endothelial cells, rat isolated working hearts subjected to…

Comparison

Hoe 694 administered at 10 M in perfusate for… vs Untreated/control hearts and animals

Design

Preclinical

Authors

WSWolfgang ScholzTU Dortmund University UAUdo AlbusGoethe University Frankfurt HLHans‐Jochen LangUniversity Hospitals of Leicester NHS Trust

Discussion

Member takes

Implication

Animal data only; leaves open whether Na+/H+ inhibition reduces reperfusion injury in patients.

Key Points

This research aims to evaluate the cardioprotective role of Hoe 694, a Na+/H+ exchange inhibitor, in cardiac ischaemia.
Rat isolated working hearts subjected to ischaemia and reperfusion with treatments including Hoe 694.
Measurement of lactate dehydrogenase and creatine kinase in venous effluent to assess cellular damage.
Pilot experiments in anaesthetized rats undergoing coronary artery ligation with Hoe 694 pretreatment.
Hoe 694 reduced reperfusion arrhythmias almost completely compared to untreated controls.
LDH and CK release decreased by 60% and 54% respectively in treated hearts.
Glycogen content increased by 60% and high energy phosphates (ATP and creatine phosphate) increased by 240% and 270%.

Structured PICO

Does the Na+/H+ exchange inhibitor Hoe 694 reduce reperfusion arrhythmias and cellular damage in rat models of cardiac ischaemia?

Population

Experimental study investigating the effects of Hoe 694 on cardiac ischaemia and reperfusion in rat isolated working hearts and anaesthetized rats.

Intervention

Hoe 694 (Na+/H+ exchange inhibitor) administered at 10(-7) M in perfusate for isolated hearts, and down to 0.1 mg kg-1 i.v. in anaesthetized rats

Comparator

Untreated/control hearts and animals

Outcome

Reperfusion arrhythmias (ventricular fibrillation, premature beats, tachycardia) and cellular damage indicators (LDH and CK release)surrogate

The novel Na+/H+ exchange inhibitor Hoe 694 demonstrates significant cardioprotective and antiarrhythmic effects during ischaemia and reperfusion in preclinical rat models.

Cite This Study

Scholz et al. (1993) studied Cardiac ischaemia and reperfusion. Hoe 694 vs. Untreated/control hearts was evaluated on Reperfusion arrhythmias and cellular damage indicators (LDH and CK). In rat models of cardiac ischaemia and reperfusion, the Na+/H+ exchange inhibitor Hoe 694 abolished reperfusion arrhythmias and reduced cellular damage indicators LDH and CK by 60% and 54%.

synapsesocial.com/papers/6a221b9ae8ef4064f24ebec6 https://doi.org/10.1111/j.1476-5381.1993.tb13607.x

Topics

Women and heart disease

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Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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