Equine cardiac troponin I has a unique 6-amino-acid deletion that does not interfere with its detection by commercial troponin I analyzers, supporting their use in veterinary medicine.
May support commercial analyzer use in equines; extends troponin validation to horses but remains hypothesis-generating.
The analysis of cardiac troponin I (cTnI) in the diagnosis of myocardial injury in domestic animals is gaining popularity. In this study, equine cTnI was sequenced and compared with previously characterized cTnI from other species. A 6-amino-acid N-terminal deletion unique to the horse was identified. This deletion was outside the epitope region of cTnI recognized by most commercial immunoassays and did not affect the ability of a commercial analyzer system to detect recombinant equine cTnI. No function could be ascribed to the deleted portion. These data support the use of commercial analyzers in measuring equine cTnI.
No takes yet. Share an insight, caveat, or question.
Mark Rishniw (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: