What question did this study set out to answer?

To evaluate serum total creatine kinase and subunit B activity following elective electrical cardioversion to identify the extent and source of procedural tissue damage.

August 1, 1990European Heart Journal

Enzyme release after elective cardioversion

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Why the study?

Does elective electrical cardioversion cause enzyme release indicative of skeletal or myocardial damage in patients?

Key Points

To evaluate serum total creatine kinase and subunit B activity following elective electrical cardioversion to identify the extent and source of procedural tissue damage.
Monitored 30 patients undergoing elective electrical cardioversion across a 28-hour post-procedure observation window.
Measured total serum creatine kinase (S-CK) and creatine kinase subunit B (S-CK-B) concentrations and analyzed their relationship with cumulative delivered electrical energy.
Mean S-CK increased from baseline (72 ± 6 U/l) to a maximum of 990 ± 258 U/l, while mean S-CK-B rose from 3.0 ± 0.6 U/l to a peak of 10.2 ± 1.8 U/l, exceeding the myocardial infarction cutoff in seven patients.
Peak activities of both S-CK (r = 0.79, P < 0.001) and S-CK-B (r = 0.70, P < 0.001) correlated significantly with cumulative delivered energy, with relative enzyme proportions indicating a skeletal muscle source.

Structured PICO

Does elective electrical cardioversion cause enzyme release indicative of skeletal or myocardial damage in patients?

Population

30 patients undergoing elective electrical cardioversion

Intervention

Elective electrical cardioversion

Outcome

Total creatine kinase (S-CK) and S-CK-B activity in serum over a 28-hour observation periodsurrogate

Enzyme release after elective cardioversion is of skeletal muscle origin and correlates with cumulative energy delivered, which may confound the diagnosis of myocardial infarction.

Discussion

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Implication

May confound post-cardioversion MI diagnosis; supports energy-dependent skeletal CK release in observational data.

Cite This Study

Jakobsson et al. (1990) studied this question.

synapsesocial.com/papers/6a868db837ab34a04c2d77db https://doi.org/10.1093/oxfordjournals.eurheartj.a059790

Topics

Atrial fibrillation Persistent AF management

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Enzyme release after elective cardioversion

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Enzyme release after elective cardioversion

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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