Key result
Sequential determination of S-CK and S-CK B 10-20 hours after symptom onset yields a diagnostic sensitivity of 0.99 and specificity greater than 0.95 for acute myocardial infarction.
Why the study?
Does the SCE diagnostic strategy using S-CK and S-CK B improve the diagnostic sensitivity and specificity for acute myocardial infarction compared to the 3% CK B limit?
Does the SCE diagnostic strategy using S-CK and S-CK B improve the diagnostic sensitivity and specificity for acute myocardial infarction compared to the 3% CK B limit?
A diagnostic strategy using sequential S-CK and S-CK B measurements with a 12 U/l discriminator provides high sensitivity and specificity for detecting acute myocardial infarction.
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May support sequential CK assays for AMI diagnosis; leaves open validation against modern troponin standards.
Gerhardt et al. (1983) conducted a review in Suspected Acute Myocardial Infarction. Sequential S-CK and S-CK B testing was evaluated on Diagnostic sensitivity and specificity for acute myocardial infarction. Sequential determination of S-CK and S-CK B 10-20 hours after symptom onset yields a diagnostic sensitivity of 0.99 and specificity greater than 0.95 for acute myocardial infarction.
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