What question did this study set out to answer?

To evaluate the diagnostic accuracy and clinical efficacy of measuring serum creatine kinase B subunit activity in patients presenting with suspected acute myocardial infarction.

May 1, 1980HeartOpen Access

Serum creatine kinase B subunit activity in diagnosis of acute myocardial infarction.

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Authors

LLL G LjungdahlMerck & Co., Inc., Rahway, NJ, USA (United States)WGW. GerhardtMultiple Sclerosis Society SHS HofvendahlKarolinska University Hospital

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Implication

Diagnostic cohort study demonstrates high predictive value of serum creatine kinase B activity in suspected acute myocardial infarction, indicating strong reliability for early cardiac detection.

Key Points

To evaluate the diagnostic accuracy and clinical efficacy of measuring serum creatine kinase B subunit activity in patients presenting with suspected acute myocardial infarction.
Assessed 238 consecutive patients admitted to a coronary care unit with suspected acute myocardial infarction (prevalence 0.47).
Measured serum CK B subunit activity using an immunoinhibition method with anti-M antibodies, comparing results against standard electrocardiographic and multienzyme diagnostic criteria.
Serum CK B subunit activity demonstrated a positive predictive value of 0.97 and a negative predictive value of 0.99 for acute myocardial infarction.
CK B subunit activity elevated beyond the diagnostic threshold within 12 hours of symptom onset.
Transient presence of the CK-BB isoenzyme led to elevated CK B activity in two non-infarction patients resuscitated from cardiac arrest.

Cite This Study

Ljungdahl et al. (1980) studied this question.

synapsesocial.com/papers/6a73f90f8055c84dbef16982 https://doi.org/10.1136/hrt.43.5.514

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Implication

Diagnostic cohort study demonstrates high predictive value of serum creatine kinase B activity in suspected acute myocardial infarction, indicating strong reliability for early cardiac detection.

Serum creatine kinase B subunit activity in diagnosis of acute myocardial infarction.

Discussion

Member takes

Implication

Key Points

Cite This Study

Serum creatine kinase B subunit activity in diagnosis of acute myocardial infarction.

Discussion

Member takes

Implication

Key Points

Cite This Study

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