Key result
Patients with acute myocardial infarction had significantly higher serum levels of Troponin I (20.12 vs 0.02 ng/ml) and CK-MB (128 vs 3.7 ng/ml) compared to healthy controls.
Why the study?
Does the measurement of serum Troponin I and CK-MB accurately diagnose acute myocardial infarction in patients with suspected MI?
Case-Control (n=80)
No
Does the measurement of serum Troponin I and CK-MB accurately diagnose acute myocardial infarction in patients with suspected MI?
Absolute Event Rate: 20.12% vs 0.02%
p-value: p=0.0016
Serum Troponin I and CK-MB are significantly elevated in acute myocardial infarction and show strong correlation, confirming their utility as diagnostic biomarkers.
Supports troponin I and CK-MB elevation in AMI; leaves open diagnostic accuracy in suspected cases.
A myocardial infarction is the irreversible necrosis of heart muscle secondary to prolonged ischemia, that occurs when a portion of the heart is deprived of oxygen due to rupture of a vulnerable plaque of a coronary artery.The present study was undertaken to evaluate the usefulness of serum troponin I and Creatine kinase-MB in the clinical diagnosis of patients with suspected acute myocardial infraction through the chemical eye.This prospective study was carried out during the period from 2013 to 2015 on fifty patients with myocardial infarction and the results obtained were compared with thirty normal subjects.Serum Troponin I and Creatine kinase-MB were measured by Enzyme-Linked Immunosorbent Assay.The results revealed that the levels of serum Troponin I and Creatine kinase-MB activity in patients with myocardial infraction were significantly higher (P< 0.01) compared with normal healthy subjects.In addition, according to our data a strong correlation can be observed between Troponin I and Creatine kinase MB.In the frame of this work we investigated that the myocardial infarction had significant effect on serum Troponin I and Creatine kinase-MB, consequently, these biochemical parameters together may be useful as an additional follow up tools in those with suspected acute myocardial infraction.
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Zrari et al. (2016) conducted a case-control in Acute Myocardial Infarction (n=80). Acute myocardial infarction vs. Healthy controls was evaluated on Serum Troponin I level (ng/ml) (p=0.0016). Patients with acute myocardial infarction had significantly higher serum levels of Troponin I (20.12 vs 0.02 ng/ml) and CK-MB (128 vs 3.7 ng/ml) compared to healthy controls.
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