Why the study?
Sepsis is frequently complicated by myocardial damage, but data on myocardial damage in rabbit caecal ligation and puncture models are limited.
Population
Rabbits undergoing experimental caecal ligation and puncture
Comparison
Experimental group vs control group
Design
Animal experimental study
Follow-up
12 h
Authors
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Rabbit CLP model may capture sepsis myocardial injury; leaves open translation to human disease and practice.
The rabbit caecal ligation and puncture model successfully demonstrates sepsis-associated myocardial damage, characterized by elevated serum cTnI and altered cardiomyocyte cTnI immunoreactivity.
Tümer et al. (2019) studied this question.
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