Key result
Peak cardiac troponin I correlates with anatomic injury and LV dysfunction in isolated rabbit hearts.
Why the study?
Does cardiac troponin I correlate with anatomic injury and left-ventricular dysfunction following experimental myocardial contusion in a rabbit model?
Population
Isolated preparation of rabbit's heart
Comparison
Global trauma vs Control group (no trauma)
Design
Preclinical
Follow-up
60 minutes
Authors
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Supports troponin I as injury marker in experimental contusion; hypothesis-generating and leaves open human translation.
Does cardiac troponin I correlate with anatomic injury and left-ventricular dysfunction following experimental myocardial contusion in a rabbit model?
Effect estimate: rho = 0.596
p-value: p=0.001
In a rabbit model of myocardial contusion, cardiac troponin I release correlates with both histologic injury and left-ventricular dysfunction, supporting its use as a marker for posttraumatic cardiac complications.
Okubo et al. (2000) studied Myocardial contusion. Global trauma vs. Control group was evaluated on Correlation of peak cardiac troponin I level with anatomic injury and left-ventricular dysfunction (rho = 0.596, p=0.001). In an isolated rabbit heart model, peak cardiac troponin I level correlated with anatomic injury (rho = 0.596, P=0.001) and negatively correlated with left-ventricular dysfunction (r = -0.375, P=0.04).
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