Why the study?
Does routine screening for coagulation inhibitors identify true deficiencies without excessive false positives in women starting oral contraceptives?
Population
2674 women recruited to participate in a multicenter oral contraceptive study on hemostasis in Germany
Design
Cohort
Authors
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High false-positive rates caution against routine unselected screening before oral contraceptives; leaves open targeted testing in women with family history of thrombosis.
Does routine screening for coagulation inhibitors identify true deficiencies without excessive false positives in women starting oral contraceptives?
Routine unselected screening for coagulation inhibitors before prescribing oral contraceptives is not recommended due to a high rate of false-positive results, though it may be feasible in those with a family history of thromboembolic disease.
Winkler et al. (1996) studied this question.
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