Why the study?
Does inhibition of the myostatin/activin signaling pathway induce muscle hypertrophy independently of satellite cells in mouse models?
Does inhibition of the myostatin/activin signaling pathway induce muscle hypertrophy independently of satellite cells in mouse models?
Inhibition of the myostatin/activin signaling pathway induces muscle hypertrophy primarily through myofibers rather than satellite cells, suggesting it could be an effective therapy even in diseases with satellite cell dysfunction.
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Myostatin/activin blockade may induce hypertrophy via myofibers without satellite cells; leaves open translation to human satellite cell disorders.
Lee et al. (2012) studied this question.