December 6, 2025American Journal of Preventive CardiologyOpen Access

Compared with MHNO, HFpEF risk was increased in MHO (HR 1.77, 95% CI 1.39-2.26), MUNO (HR 1.59, 95% CI 1.27-1.99) and MUO (HR 2.77, 95% CI 2.25-3.40), while HFrEF/HFmrEF risk was higher in MUNO (HR 1.61, 95% CI 1.27-2.04) and MUO (HR 2.19, 95% CI 1.74-2.75).

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Why the study?

Obesity and metabolic unhealth do not always coexist, and the relationship between metabolic obese phenotypes and risk of HF subtypes categorized by LVEF was unclear.

Do metabolic obese phenotypes increase the risk of future heart failure subtypes compared to metabolically healthy non-obese individuals?

Population

9791 participants from the ARIC study

Comparison

MHO, MUNO, and MUO vs MHNO

Design

Cohort study

Authors

BDBin Dong JLJiayong Li YNYu Ning

Discussion

Member takes

Overview

Metabolic-obese phenotypes may stratify HF subtype risk; leaves open causal validation before practice change.

Structured PICO

Do metabolic obese phenotypes increase the risk of future heart failure subtypes compared to metabolically healthy non-obese individuals?

Population

9791 participants from the ARIC study

Intervention

Metabolic obese phenotypes (metabolically healthy obesity [MHO], metabolically unhealthy non-obesity [MUNO], and metabolically unhealthy obesity [MUO])

Comparator

Metabolically healthy non-obesity (MHNO)

Outcome

Risk of heart failure with preserved ejection fraction (HFpEF, LVEF ≥ 50 %) and heart failure with reduced or mid-range ejection fraction (HFrEF/HFmrEF, LVEF < 50 %)hard clinical

Metabolically unhealthy phenotypes are associated with increased risk of all HF subtypes, whereas metabolically healthy obesity is specifically associated with an increased risk of future HFpEF but not HFrEF/HFmrEF.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/6a8699d607201076d3544ebc https://doi.org/10.1016/j.ajpc.2025.101365

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December 6, 2025American Journal of Preventive CardiologyOpen Access

Compared with MHNO, HFpEF risk was increased in MHO (HR 1.77, 95% CI 1.39-2.26), MUNO (HR 1.59, 95% CI 1.27-1.99) and MUO (HR 2.77, 95% CI 2.25-3.40), while HFrEF/HFmrEF risk was higher in MUNO (HR 1.61, 95% CI 1.27-2.04) and MUO (HR 2.19, 95% CI 1.74-2.75).

View Full Paper

Ask AI

Bookmark

Why the study?

Obesity and metabolic unhealth do not always coexist, and the relationship between metabolic obese phenotypes and risk of HF subtypes categorized by LVEF was unclear.

Do metabolic obese phenotypes increase the risk of future heart failure subtypes compared to metabolically healthy non-obese individuals?

Population

9791 participants from the ARIC study

Comparison

MHO, MUNO, and MUO vs MHNO

Design

Cohort study

Authors

BDBin Dong JLJiayong Li YNYu Ning

Discussion

Member takes

Overview

Metabolic-obese phenotypes may stratify HF subtype risk; leaves open causal validation before practice change.

Structured PICO

Do metabolic obese phenotypes increase the risk of future heart failure subtypes compared to metabolically healthy non-obese individuals?

Population

9791 participants from the ARIC study

Intervention

Metabolic obese phenotypes (metabolically healthy obesity [MHO], metabolically unhealthy non-obesity [MUNO], and metabolically unhealthy obesity [MUO])

Comparator

Metabolically healthy non-obesity (MHNO)

Outcome

Risk of heart failure with preserved ejection fraction (HFpEF, LVEF ≥ 50 %) and heart failure with reduced or mid-range ejection fraction (HFrEF/HFmrEF, LVEF < 50 %)hard clinical

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/6a8699d607201076d3544ebc https://doi.org/10.1016/j.ajpc.2025.101365

View Full Paper

Ask AI

Bookmark