March 16, 2012ObesityOpen Access

From Metabolic Normality to Cardiometabolic Risk Factors in Subjects With Obesity

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Why the study?

Does overweight or obese status increase the incidence of cardiometabolic risk factors compared to normal body weight in metabolically normal subjects?

Population

436 subjects from the RISC study who were metabolically normal at baseline.

Comparison

Overweight or obese (ow/ob) status vs Normal body weight (nbw) status

Design

Cohort

Follow-up

3 years

Authors

EBElisabetta Bobbioni‐HarschUniversity Hospital of Geneva ZPZoltan PatakyUniversity of Pisa VMVincent MakoundouUniversity of Geneva

Discussion

Member takes

Implication

May warrant closer monitoring in metabolically healthy overweight/obese patients; leaves open whether weight reduction prevents risk factor onset.

Structured PICO

Does overweight or obese status increase the incidence of cardiometabolic risk factors compared to normal body weight in metabolically normal subjects?

Population

436 subjects (284 normal body weight and 152 overweight/obese) from the RISC study who were metabolically normal at baseline (no impaired fasting glucose, reduced HDL-cholesterol, increased plasma triglycerides, increased blood pressure, or impaired glucose tolerance).

Intervention

Overweight or obese (ow/ob) status

Comparator

Normal body weight (nbw) status

Outcome

Incidence of one or more cardiometabolic risk factors (impaired fasting glucose, reduced HDL-cholesterol, increased plasma triglycerides, increased blood pressure, or impaired glucose tolerance) at 3 yearssurrogate

Metabolically normal overweight and obese subjects have a significantly higher incidence of developing cardiometabolic risk factors over a short 3-year follow-up compared to normal-weight individuals.

Cite This Study

Bobbioni‐Harsch et al. (2012) studied this question.

synapsesocial.com/papers/6a8699d807201076d3544ec3 https://doi.org/10.1038/oby.2012.69

Topics

Women and heart disease

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Implication

May warrant closer monitoring in metabolically healthy overweight/obese patients; leaves open whether weight reduction prevents risk factor onset.

From Metabolic Normality to Cardiometabolic Risk Factors in Subjects With Obesity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

From Metabolic Normality to Cardiometabolic Risk Factors in Subjects With Obesity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider