Key result
Metabolic disease in CAD is linked to ~0.04 mm greater carotid IMT versus healthy individuals.
Why the study?
The influence of obesity and metabolic abnormalities on carotid intima media thickness in patients with coronary artery disease was not well defined.
Does the presence of metabolic abnormalities and obesity influence carotid intima media thickness in patients with coronary artery disease?
Population
1002 participants with coronary artery disease from the CordioPrev study
Comparison
Metabolically sick phenotype and obesity/overweight vs metabolically healthy phenotype and normal weight
Design
Cross-sectional study
Authors
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May indicate higher atherosclerotic burden in metabolically unhealthy CAD; cross-sectional data leaves open causality and prospective validation.
Cross-Sectional (n=939)
Single-blind
Yes
Does the presence of metabolic abnormalities and obesity influence carotid intima media thickness in patients with coronary artery disease?
Absolute Event Rate: 0.73% vs 0.69%
p-value: p=4 * 10^-6
In patients with coronary artery disease, a metabolically abnormal phenotype is associated with greater carotid intima media thickness, suggesting higher cardiovascular risk, while obesity blunts the protective effect of being metabolically healthy.
Talavera-Garcia et al. (2016) conducted a cross-sectional in Coronary Artery Disease (n=939). Metabolic disease (≥2 metabolic abnormalities) vs. Metabolically healthy (<2 metabolic abnormalities) was evaluated on Carotid intima media thickness (IMT-CC) (p=4 * 10^-6). In patients with coronary artery disease, the presence of metabolic disease was associated with a significantly greater carotid intima-media thickness compared to metabolically healthy individuals (0.73 mm vs 0.69 mm).
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