Why the study?
MetS and obesity are risk factors for atherosclerosis, but their combined impact on subclinical atherosclerosis risk is unknown.
Does the co-occurrence of metabolic syndrome and obesity increase carotid intima media thickness compared to either condition alone in women without clinical cardiovascular disease?
Population
1,433 women with BMI ≥18.5 kg/m 2 free of clinical cardiovascular disease
Comparison
Co-occurrence of MetS and obesity vs either alone or neither
Design
Multi-center multi-ethnic cross-sectional study
Authors
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MetS may predominate over obesity in driving carotid thickening; leaves open whether MetS-targeted interventions modify subclinical atherosclerosis in midlife women.
Does the co-occurrence of metabolic syndrome and obesity increase carotid intima media thickness compared to either condition alone in women without clinical cardiovascular disease?
In women without clinical cardiovascular disease, obesity adds minimal impact on carotid artery thickness beyond metabolic syndrome alone, suggesting all individuals with metabolic dysfunction are at increased risk for atherosclerotic changes.
Leis et al. (2023) studied this question.
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