Why the study?
Does high-dose methotrexate with folinic acid rescue provide acceptable toxicity and efficacy in adults with malignant disease?
Does high-dose methotrexate with folinic acid rescue provide acceptable toxicity and efficacy in adults with malignant disease?
High-dose methotrexate with folinic acid rescue shows acceptable toxicity and encouraging results in some adults with malignant disease, though strict protocol adherence is necessary to prevent fatal toxicity.
Requires strict protocol adherence to avoid fatalities; leaves open efficacy confirmation in controlled adult trials.
Eighty-six adults with malignant disease were given high doses of methotrexate with folinic acid rescue, with acceptable toxicity. Protocal violations in two cases led to death. The results of therapy in some diagnostic groups are encouraging.
No takes yet. Share an insight, caveat, or question.
Bell et al. (1977) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: