Population
36-year-old woman with osteosarcoma undergoing preoperative chemotherapy (n=1)
Design
Case_report
Follow-up
approximately 1.5 months
Authors
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High-dose methotrexate may trigger acute arrhythmias; this case report leaves open causality and need for prospective confirmation.
High-dose methotrexate can cause acute cardiac symptoms and arrhythmias in previously healthy adults, highlighting a potential cardiotoxic effect that warrants clinical awareness.
Perez‐Verdia et al. (2005) studied this question.
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