Why the study?
Does methotrexate cause ventricular arrhythmias in a patient with prior myocardial infarction?
Population
A 36-year-old male with a history of large anterior myocardial infarction and cardiac arrest 1 year prior…
Comparison
Oral methotrexate, single weekly doses up to 10… vs Discontinuation of methotrexate therapy.
Design
Case_report
Follow-up
A few months
Authors
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May signal methotrexate proarrhythmia risk post-MI; single case leaves open generalizability and causality.
Does methotrexate cause ventricular arrhythmias in a patient with prior myocardial infarction?
This case report highlights a potential proarrhythmic effect of methotrexate in a patient with structural heart disease, demonstrated by positive dechallenge and rechallenge.
Kettunen et al. (1995) studied this question.
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