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Methotrexate A Cause of Myocarditis, Myth or Reality?

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Case report reveals methotrexate may induce myocarditis in a diabetic patient, highlighting monitoring needs.

Acute myocarditis developed in a diabetic patient treated with methotrexate for rheumatoid arthritis, and symptoms resolved upon discontinuation.
The patient's cardiac MRI indicated lower limb edema and segmental left ventricular dysfunction, emphasizing the drug's potential risk.
Although definitive causation couldn't be confirmed without a myocardial biopsy, the presentation suggests a drug-induced etiology.
The findings highlight the need for vigilant monitoring of patients on immunosuppressive therapy, especially regarding cardiac side effects.

Nguadi et al. (2025) studied this question.

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