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This case outlines the toxicity associated with methotrexate in a rheumatoid arthritis patient due to incorrect dosing.

July 13, 2026Open Access

Methotrexate Toxicity in a Rheumatoid Arthritis Patient

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Case presentation shows serious methotrexate toxicity in a patient, highlighting the need for careful monitoring and education.

This case outlines the toxicity associated with methotrexate in a rheumatoid arthritis patient due to incorrect dosing.
Case presentation of a 58-year-old female with seropositive rheumatoid arthritis.
Laboratory investigations included liver enzyme levels, kidney function, and blood counts.
Treatment involved discontinuation of methotrexate and initiation of intravenous leucovorin rescue therapy.
Patient experienced severe pancytopenia and elevated liver enzymes after accidental daily dosing.
Immediate discontinuation of methotrexate and supportive care led to gradual recovery during hospitalization.
Emphasized the importance of patient education on proper dosing schedules to prevent medication errors.

Saron Micahvel S.1, Dr. Pallavi Singh*2, Dr. Karthickeyan Krishnan3, Shanmugasundaram Palani4 (2026) studied this question.

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