What question did this study set out to answer?

To explore the risks associated with methotrexate therapy in patients with renal impairment and highlight toxic effects.

791: Methotrexate: To Give or Not to Give in Patients With Renal Failure

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Case report highlights the effects of methotrexate toxicity in patients with renal failure, suggesting careful treatment consideration.

To explore the risks associated with methotrexate therapy in patients with renal impairment and highlight toxic effects.
Presented a case study of a 76-year-old man with renal failure and rheumatoid arthritis.
Monitored clinical symptoms including shortness of breath and tongue swelling post methotrexate administration.
Conducted laboratory tests revealing pancytopenia and hyperkalemia, indicating toxicity.
Patient developed severe mucositis leading to respiratory distress and septic shock.
Underwent aggressive treatment including dialysis and antibiotics for Candida infection.
Despite intensive care, the patient passed away, highlighting the dangers of methotrexate in renal failure.

FRIMERMAN et al. (2026) studied this question.

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