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September 10, 2025Journal of Medical CasesOpen Access

A Clinical Case of Methotrexate Toxicity

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A case report identifies severe toxicity from improper dosing of methotrexate in an elderly patient, highlighting medication safety.

Methotrexate toxicity led to serious complications, including erosive mucositis and pancytopenia.
The elderly patient mistakenly took methotrexate daily instead of weekly, resulting in significant adverse effects.
Immediate discontinuation of methotrexate and supportive care improved the patient's condition.
Early recognition and effective communication are crucial for preventing adverse outcomes with methotrexate.

Peixoto et al. (2025) studied this question.

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