Why the study?
Methotrexate has a narrow therapeutic index and, if unmonitored, can lead to life-threatening complications.
Comparison
Daily MTX dose instead of prescribed weekly dose
Design
Case report
Authors
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Dosing errors with methotrexate warrant heightened vigilance; this case leaves open the need for systematic safety protocols.
Unmonitored methotrexate therapy and dosing errors can lead to life-threatening complications including ventricular arrhythmia and cardiogenic shock.
Shah et al. (2019) studied this question.
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