Case report demonstrates catastrophic acute toxicity from low-dose methotrexate in renal impairment, highlighting the necessity of rapid multidisciplinary intervention.
Catastrophic methotrexate toxicity, characterized by life‐threatening pancytopenia and neutropenic enterocolitis, may occur even after a single low therapeutic dose, particularly in patients with renal impairment or dehydration. Early recognition and prompt multidisciplinary management are essential to improve outcomes.
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Asgari et al. (2026) studied this question.
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