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March 25, 2025Saudi Journal of AnaesthesiaOpen Access

Effect of ultrasound-guided PecS II block on the incidence of chronic postmastectomy pain in patients after radical mastectomy: A randomized controlled trial

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Authors

HHHuiying HuBLBixi LiTWTingting Wang

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Overview

Randomized trial reveals ultrasound-guided PecS II block reduces chronic postmastectomy pain at 12 weeks in mastectomy patients, indicating improved recovery and decreased opioid reliance.

Key Points

  • To assess the effect of ultrasound-guided pectoral nerve (PecS) II block on the incidence of chronic postmastectomy pain and perioperative opioid requirements following radical mastectomy.
  • Randomized controlled trial (ChiCTR2200066968) enrolling 98 patients undergoing elective radical mastectomy, randomly assigned to receive either an ultrasound-guided PecS II block (group P) or standard care without the block (group C).
  • Evaluated the primary outcome of chronic pain incidence at 12 weeks post-surgery, alongside secondary outcomes including intraoperative remifentanil, 48-hour postoperative oxycodone consumption, time to first rescue analgesia, and Hospital Anxiety and Depression Scale (HADS) scores.
  • The incidence of chronic pain at 12 weeks post-surgery was significantly lower in the PecS II block group compared to the control group (20.65% vs. 34.78%, P < 0.05).
  • Patients receiving the block required significantly less intraoperative remifentanil (1.46 ± 0.11 mg vs. 2.66 ± 0.18 mg, P < 0.001) and less oxycodone within 48 hours postoperatively (22.57 ± 3.21 mg vs. 31.62 ± 4.71 mg, P < 0.001).
  • Time to first analgesic request was significantly prolonged in the block group (368.80 ± 157.68 min vs. 96.60 ± 40.12 min, P < 0.001), with corresponding reductions in 48-hour acute pain scores and HADS scores at 48 hours and 12 weeks (P < 0.05).

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/6a869ecb2ddf18dfdd75ecf2https://doi.org/10.4103/sja.sja_398_24
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Study between Pectoral Nerve Block Type-II (PECS II) and Serratus Anterior Plane Block (SAPB) in Postoperative Analgesic Efficacy in Modified Radical Mastectomy2024 · 1 citations
  2. 2Evaluation of ultrasound guided pectoralis nerve block for post-operative analgesia in patients undergoing modified radical mastectomy under general anaesthesia2024
  3. 3Comparison of Acute Postoperative Pain Between Preemptive Ultrasound-Guided Pectoral Nerve Block and Intraoperative Pectoral Nerve Block in Patients Undergoing Mastectomy2025
  4. 4Pectoral Nerves Blocks for Post-Operative Analgesia after BreastCancer Surgery2021 · 2 citations
  5. 5Efficacy of Peripheral Nerve Stimulator Guided Pectoral Nerve Block-1 and Serratus Anterior Plane Block for Post-operative Analgesia in Modified Radical Mastectomy: A Randomized Controlled Study2024