Population
Cultured neonatal rat atrial and ventricular myocytes
Comparison
Brefeldin A vs Control (untreated cells)
Design
Preclinical
Authors
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Distinguishes constitutive ventricular from regulated atrial ANF secretion in animals; hypothesis-generating for human natriuretic peptide regulation.
Basal ANF secretion from ventricular cells is constitutive and relies on newly synthesized hormone, whereas atrial ANF secretion is regulated and independent of newly synthesized protein transport.
Young et al. (1994) studied this question.
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