October 1, 2003AJP Heart and Circulatory Physiology
Right ventricular volume measurement by conductance catheter
Why the study?
Does right ventricular volume measurement by conductance catheter accurately reflect volumes measured by MRI in a porcine model?
Population
Anesthetized pigs (n = 5, 45-55 kg)
Comparison
Right ventricular volume measurement using a… vs Right ventricular volume measurement using…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Calibrated conductance catheters enable accurate RV volumetry in pigs; leaves open human translation and clinical validation.
Key Points
- To assess the accuracy, limitations, and linearity of conductance catheter measurements for right ventricular volume compared against reference magnetic resonance imaging.
- Evaluated 5 anesthetized pigs (45–55 kg) using 1.5-T ECG-gated transverse MRI and Simpson's technique to establish reference right ventricular volumes.
- Instrumented subjects with an RV conductance catheter testing single-field (SF) and dual-field (DF) excitations alongside an ultrasonic pulmonary artery flow probe, correcting for parallel conductance via saline dilution.
- Calibrated conductance volumes demonstrated high linear correlation with MRI volumes (r = 0.96 for SF, r = 0.94 for DF) with a slight curvilinear concavity toward the MRI axis.
- The gain factor varied significantly across the cardiac cycle under SF excitation (0.49 at end systole vs 0.39 at end diastole, P = 0.011), whereas DF excitation improved stroke volume gain factor (0.96 vs 0.41) and stabilized cycle variation (1.0 vs 0.92, P = 0.66).
Structured PICO
Does right ventricular volume measurement by conductance catheter accurately reflect volumes measured by MRI in a porcine model?
P
Population
Anesthetized pigs (n = 5, 45-55 kg)
I
Intervention
Right ventricular volume measurement using a conductance catheter with single- and dual-field excitation
C
Comparator
Right ventricular volume measurement using magnetic resonance imaging (MRI)
O
Outcome
Accuracy of right ventricular volume measurement (correlation between conductance and MRI volumes)surrogate
The conductance method can measure absolute right ventricular volume under steady-state conditions with calibration, though dual-field excitation provides better accuracy and less variation than single-field.
Cite This Study
Danton et al. (2003) studied this question.