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April 1, 1977Journal of Cell Science

Studies on isolated smooth muscle cells: the contractile apparatus

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Population

Isolated smooth muscle cells from the taenia coli muscle of the guinea pig

Design

Preclinical

Authors

JSJ. Victor SmallInstitute of Molecular Biotechnology

Discussion

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Implication

Caution against applying skeletal muscle models to smooth muscle; leaves open filament shearing contributions to human vascular disorders.

Structured PICO

P
Population
Isolated smooth muscle cells from the taenia coli muscle of the guinea pig
I
Intervention
Triton X-100 (0.05%) treatment to make cells permeable, and observation under electron microscopy
O
Outcome
Structural organization of the contractile apparatus (myosin and actin filaments)surrogate

The study reveals that smooth muscle myosin filaments lack bipolarity and Z-lines, allowing for greater shearing between actin and myosin filaments compared to skeletal muscle.

Cite This Study

J. Victor Small (1977) studied this question.

synapsesocial.com/papers/6a86a43cbf8a68ea2b6ed981https://doi.org/10.1242/jcs.24.1.327
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The structure of the myosin elements in vertebrate smooth muscles1973 · 24 citations
  2. 2Filaments from Purified Smooth Muscle Myosin1973 · 18 citations
  3. 3LOCALIZATION OF MYOSIN FILAMENTS IN SMOOTH MUSCLE1968 · 104 citations
  4. 4THE DOUBLE ARRAY OF FILAMENTS IN CROSS-STRIATED MUSCLE1957 · 644 citations
  5. 5Studies on the function and composition of the 10-nm(100- å) filaments of vertebrate smooth muscle1977 · 388 citations