Why the study?
Does fluoxetine improve depression and is it safe in patients with major depression and end stage renal disease on hemodialysis?
Population
14 patients with major depression and end stage renal disease on hemodialysis
Comparison
Fluoxetine vs Placebo
Design
RCT, randomized into two groups, Subjects as well as investigators were blinded
Follow-up
8 weeks
Authors
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Fluoxetine may warrant short-term trial for depression in ESRD on hemodialysis; extends sparse RCT data to this high-risk population.
Does fluoxetine improve depression and is it safe in patients with major depression and end stage renal disease on hemodialysis?
Fluoxetine appears relatively safe and potentially efficacious for treating major depression in patients with end-stage renal disease on hemodialysis.
Blumenfield et al. (1997) studied this question.
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