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January 1, 1999Current Pharmaceutical Design

Role of Phosphodiesterase Isoenzymes in the Control of Renin Secretion: Effects of Selective Enzyme Inhibitors

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Why the study?

Do selective phosphodiesterase inhibitors affect renin secretion by the kidneys?

Design

Review

Authors

IRIan A. ReidUniversity of Nebraska at Omaha

Discussion

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Overview

PDE3/4 inhibitors may raise renin in treated patients; leaves open effects on BP control or HF outcomes.

Structured PICO

Do selective phosphodiesterase inhibitors affect renin secretion by the kidneys?

I
Intervention
Selective phosphodiesterase (PDE) inhibitors (e.g., PDE3 inhibitors milrinone and trequinsin; PDE4 inhibitors rolipram and Ro 20-1724)
O
Outcome
Renin secretionsurrogate

Selective PDE3 and PDE4 inhibitors increase renin secretion, highlighting the role of phosphodiesterases in renal renin regulation.

Cite This Study

Ian A. Reid (1999) studied this question.

synapsesocial.com/papers/6a86aca67fdf9298f89eab83https://doi.org/10.2174/1381612805666230111201536
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Section Review: Cardiovascular & Renal: Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases1995 · 64 citations
  2. 2Stimulation of renin secretion by nitric oxide is mediated by phosphodiesterase 31998 · 101 citations
  3. 3Control of Renin Secretion From Rat Juxtaglomerular Cells by cAMP-Specific Phosphodiesterases2002 · 83 citations
  4. 4Role of phosphodiesterase isoenzymes in regulating intracellular cyclic AMP in adenosine-stimulated smooth muscle cells1995 · 16 citations
  5. 5Inhibit a Phosphodiesterase to Treat Heart Failure?2018 · 16 citations