The stimulatory effects of endogenous and exogenous nitric oxide on renin secretion are mediated by a cGMP-induced inhibition of cAMP degradation via phosphodiesterase 3.
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PDE-3 mediates NO stimulation of renin secretion in animal tissue; hypothesis-generating for effects of PDE inhibitors on human renin-angiotensin axis.
Kurtz et al. (1998) studied this question.
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