Population
isolated perfused rat kidney model
Comparison
NO donor sodium nitroprusside (SNP) (1-30 mumol/l) vs basal conditions
Design
Preclinical
Authors
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NO-cAMP renin link in rodent JG cells warrants no clinical change; leaves open human pathway confirmation and therapeutic relevance.
The stimulation of renin secretion by NO donors in renal juxtaglomerular cells is causally related to the cAMP pathway rather than G kinase activation.
Kurtz et al. (1998) studied this question.
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